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Re: any serotonine enhancers intolerance, possible ?

Posted by Elizabeth on September 12, 2001, at 5:47:46

In reply to any serotonine enhancers intolerance, possible ?, posted by Sigolène on September 8, 2001, at 3:28:21

> No psychiatrist wants to believe me when i say I'm a complete serotonine enhancers intolerant. No matter which way the med. acts, i'm even intolerant to natural products like plants wich have a very small effect on serotonine. I also can't tolerate lithium because it acts on serotonine. I need a very specific norepinephrine active med, wich is not easy to find.

Hi. Why did you go off desipramine? Depending on what country you're in, there may be other selective NE reuptake inhibitors available as well. And what about mianserin, or its metabolite, mirtazapine?

An alternative would be to use a dopaminergic-noradrenergic stimulant, such as d-amphetamine or methylphenidate; bupropion, a non-serotonergic AD; or a selective MAO-B inhibitor such as selegiline (AKA l-deprenyl). Another option would be to try a serotonin reuptake inhibitor, such as tianeptine.

Do you have panic disorder or other significant anxiety? People with these problems are often serotoin-sensitive. SSRIs work by desensitising them gradually, and they usually have to start the SSRI at a very low dose and increase it very slowly, in order to be able to tolerate it.

> When I say this to any psychiatrist, they answer that if serotonine enhancers could worsen depression, it should be known for a long time, and they never heard about that. They think this king of remark is due to my "personality disorder", which makes my incapable of objective judgment... I hate hearing things like that.

That's pretty obnoxious, yeah. Have you tried looking for a more biologically-oriented psychiatrist? They tend to be less judgmental, in my experience.

-elizabeth


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