Posted by shelliR on September 12, 2001, at 22:45:01
In reply to Re: Cam, Elizabeth Waterlily, Thanks for responses, posted by SLS on September 12, 2001, at 20:58:30
> > > The thing that made me wonder if oxycontin is making my depression worse, is how horrible I feel when I wake up in the morning.
> >
> > What time do you take it at night? It sounds like rebound to me.
>
>
> Hi Shelli.
>
> For what it's worth, I agree. If this is indeed the case, you don't have to be worried that the oxycodone is somehow creating a tangled mess of your brain neurochemistry leading to a worsening of your baseline depression. In other words, you are probably experiencing a "crash" upon the loss of oxycodone activity such that the downward momentum of the crash actually leaves you temporarily below your unmedicated baseline. Were you not to reintroduce the oxycodone, you would soon recover and stabilize at a more familiar level of depression.
>
>
> - ScottThanks Scott,
Your opinion *is* reassuring to me. This morning, I actually paged the hopital pdoc who told me that opiates can interfere with anti-depressant effect. He called me back within five minutes. I specifically asked him if he had any sources he could refer me to that supported what he had said, besides the random studies , similar to the one that Sal pointed out. This pdoc admitted those studies were not particularly enlightening to my situation. And he said that my pdoc, who he has worked with, knows a lot more about biochemistry than he does, so he would defer to my pdoc. That was also reassuring.
I suppose it is not worth it to take a small dose of oxy to try to prevent waking up everyday with suicidal thoughts. I'm not even sure that I would be able to sleep (it is very activating for me); but more importantly, it would raise my dose.
BTW, I just read the posts on ketoconazole and hypercontisolemia. Interesting stuff. Have you been tested for this?
Shelli
poster:shelliR
thread:78595
URL: http://www.dr-bob.org/babble/20010907/msgs/78692.html