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Re: my new augment strategy » christophrejmc

Posted by JohnX2 on December 2, 2001, at 11:55:05

In reply to Re: my new augment strategy » JohnX2, posted by christophrejmc on December 1, 2001, at 21:19:30


Manerix is a reversible MAO-A inhibitor.
It does not have dietary restrictions by itself.
Selegiline is a MAO-B inhibitor at the
lower doses, and MAO-A at the higher dose,
but it has the dietary restrictions.
I wanted to see if I could get away with as
little Selegiline as possible, but I pretty
much needed 60 mg to get the full effect.

I found that I needed a healthy dose of
both to get this to work. I had more Manerix
on hand, so I had to budget the Selegiline.

I could probably have swapped the 2 out for
Parnate.

I think I've heard of someone else combining
Parnate with a NRI. (was it SLS?).

Reboxetine is supposed to help prevent
a hypertensive crisis on a MAOI and is actually
a safner from what I read. But I don't know
if that is true with the alpha-2 antagonist
from Remeron in there.

When the MAOI inhibitor causes more amine
to be released, or a reuptake inhibitor
is leaving more amine in the synaptic cleft,
normally it would hit the alpha-2 feedback
receptor which I believe would
decreased the tyrosine hydroxylase in the
presynaptic neuron (the rate limiting enzyme
to produce dopamine or noradrenaline). With
the alpha-2 antagonist, the reuptake inhibitor,
and MAOI inhibitor, its pretty much balls to
the wall on output. But I think it could be
toxic and dangerous.

-john

> May I ask why you combined Manerix and selegiline?
> > Remeron,Manerix,Selegiline,Reboxetine.


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