Posted by JohnX2 on January 21, 2002, at 15:59:04
In reply to Re: topamax+lamictal; + Acamprosate????, posted by JohnX2 on January 21, 2002, at 15:03:29
Hmm, just saw an abstract postulating that
Lamictal boosts brain taurine anways...interesting...-john
>
> I should add that I take a 5 mg dose of
> Zyprexa, and I believe that 5ht-2 antagonism
> may also help alleviate a bit some stimulant
> poop out.
>
> I was thinking of testing Acamprosate to my
> Lamictal + Topamax and dumping Zyprexa.
>
> Acamprosate is a simple carrier molecule for the amino
> acid Taurine which has anti-epileptic properites
> and is generally produced naturally in the brain.
> I believe it is a GabaB agonist and a mild
> NMDA antagonist. (correct me if I am wrong)
> Acamprosate has been shown to prevent
> ethanol (alcohol) tolerance. I think it may
> be a good mood stabilizer and help relieve
> agitation.
>
> With this wicked trio you would have
> your GabaA,GabaB,AMPA,NMDA all covered from
> many angles with few side effects hopefully.
> I think it could be a real home run for
> bipolar. . Just a random thought.
>
> -John
>
>
> >
> > I don't get stimulant poop out (at least
> > from taking pseuedoepedrine nasal decongestants
> > during this tree pollen crap in Austing),
> > now that I am taking Topamax with my Lamictal.
> > Caffeine doesn't crap out either like it was
> > for me before.
> >
> > I wonder if the cascaded modulation of AMPA
> > and NMDA glutamate receptors by Topamax and Lamictal
> > coupled with the increased GabaA conductance
> > by Topamax all work together to substantially lower
> > the stimulants tolerance/sensitization pathway.
> >
> > This seems quite feasable to me from what I
> > have read about the addiction pathway.
> >
> > It's curious that when I added Topamax on Lamictal
> > I got no typical glutamate side effects like blurry
> > vision, slurred speech, etc. Any other anti-convulsant
> > I added to Lamictal had the usual side effects. I wonder
> > if there is a interesting synergy when one combines
> > the two meds. Alas, I seem to be one of the 1st
> > guinea pigs...
> >
> > -John
poster:JohnX2
thread:90939
URL: http://www.dr-bob.org/babble/20020116/msgs/91024.html