Posted by geno on April 7, 2002, at 17:35:57
In reply to Re: What is the Most Sedating Dose of Remeron? » colin wallace, posted by fachad on April 7, 2002, at 7:42:06
iv been using remeron for about 1 yr or more. i started at 30mg which was nice, for first week, sedated but that wore off. Its a great sleeping pill, antianxiety pill, ad all in one. To give you some pharmocology, at 15mg, it targets the histamine 1 blockade, causing sedation. at 30mg, it targets both h1 and 5ht2 receptor blockade, at 45mg and above, it blocks alpha 2 ne. I actually upped my remeron to 45mg and had a hard time falling asleep, and felt more arousal. Im sure 60mg for me would be activating, and good for sexual dysph.
I also take 25mg of desipramine, to counteract some of remerons sedation. Some side effects are increase sweating and heart rate. But now, when i get zoloft up to 100mg, my pdoc is dropping desipramine. If zoloft kills my sex drive, i may up the remeron to 45mg at night with some ambien.
if you suffer from extreme insominia, 15mg to start is good. even 30 knock me out. alpha 2 NE blockade is good for arousal. Maybe to augement SSRI sexual dysph. exp paxil. killed my sex drive making me more depressed.
geno
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