Posted by mat on April 16, 2002, at 17:09:51
In reply to SNRIs: Desipramine vs. Reboxetine » geno, posted by fachad on April 16, 2002, at 16:19:19
hi fachad
everything you posted is of course true and is exactly what my pharmacology-textbooks says, but remember:
1. the affinity of desipramine for muscarinic receptors is about 34 times higher
2. for h1-receptors about 3 times higher
3. for alpha1-receptors about 90 times higher
maybe that makes the difference, and is the reason for the hype (is there really a hype about reboxetine? and-do you know any reasons why the fda rejected its approval?)
thank's for your reply
mat
poster:mat
thread:103083
URL: http://www.dr-bob.org/babble/20020416/msgs/103265.html