Posted by SLS on April 18, 2002, at 10:00:18
In reply to Re: SNRIs: Desipramine vs. Reboxetine » SLS, posted by mat on April 18, 2002, at 6:52:24
> hi scott
> interestingly, i recently experienced the same worsening of my depression, but while taking another drug that's often prescribed here in austria-milnacipran (a serotonin and noradrenalin ri).
> there was no anxiety, but i think i was suicidal for the first time in my life. i discontinued it-and felt MUCH better on the next morning (neither i nor my pdoc could believe that). of course, nobody can predict how one will react to a specific drug, but i nevertheless
> do think that the noradrenergic component of milnacipran was at least partially reponsible for my exacerbation. maybe that's a simplicistic view of how antidepressants work, but at least it's a method for me to (try to) understand what could go wrong in my brain (and THAT'S very important for me!)
Hi Mat.I think it is very useful to observe trends in how one reacts to medication and look for associations based upon what is known about them. However, I have sometimes reacted to drugs in ways that seem counterintuitive or contradictory to the pharmacological properties that are currently described for them. I would not exclude Celexa from the drugs I will try in the future (if necessary) simply because I did not respond adequately to Prozac and Paxil. There are a huge number of people whom respond to one SSRI after having failed to respond to other SSRIs previously.
Specific people react to specific drugs for specific reasons. I think this should be the theorem upon which the pursuit of understanding is based. I just don't think we are there just yet.
- Scott
poster:SLS
thread:103083
URL: http://www.dr-bob.org/babble/20020416/msgs/103424.html