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Re: Bekka H- Lamictal tyrosine/dopamine depletion » 3 Beer Effect

Posted by TSA West on April 27, 2002, at 1:24:50

In reply to Bekka H- Lamictal tyrosine/dopamine depletion, posted by 3 Beer Effect on April 27, 2002, at 0:37:47

Esteemed Sir,

Thank you for that information, and dopamine depletion is a definite possibility with Lamotrigine. However, Lamotrigine's action on serotonin is overwhelmingly valuable to the bipolar and unipolar population, possibly negating any effect that Lamotrigine has on dopamine:

Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Eur J Pharmacol. 1998 Sep 25;358(1):19-24:
"The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake in vivo. These effects probably reflect an affinity for biogenic amine transporters..."

Erfurth A, Amann B, Grunze H. Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?
Neuropsychobiology. 1998 Oct;38(3):200-1:
"The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake..."

Kumar TC, Khanna S.
Lamotrigine augmentation of serotonin re-uptake inhibitors in obsessive-compulsive disorder.
Aust N Z J Psychiatry. 2000 Jun;34(3):527-8.

Shiah IS, Yatham LN, Lam RW, Zis AP. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
J Affect Disord. 1998 May;49(2):157-62.

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