Posted by katekite on April 27, 2002, at 10:54:00
In reply to Bekka H- Lamictal tyrosine/dopamine depletion, posted by 3 Beer Effect on April 27, 2002, at 0:37:47
That was a great post 3beers.
I seem to have a good response to as little as 2.5 of ritalin but so far nothing to dexedrine (except decreased apetite) (although dex does stop my rebound from ritalin so it must do a little something), and am wondering how its possible. I'm trying to be cautious with the dex but so far it seems like a placebo almost.
Any thoughts? Does dex inhibit the dopamine transporter or mostly cause release? I know ritalin supposedly does not cause release but does inhibit the dopamine transporter.
This is interesting regarding dex and ritalin and serotonin, but don't have the full article so don't know what they mean by 'hi-dose':
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Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function.
Fleckenstein AE, Haughey HM, Metzger RR, Kokoshka JM, Riddle EL, Hanson JE, Gibb JW, Hanson GR.
Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East RM 201, Salt Lake City, UT, USA. fleckenstein@msscc.med.utah.edu
High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter function in vivo, as assessed in striatal synaptosomes obtained from drug-treated rats. In contrast, high-dose injections of fenfluramine, cocaine or methylphenidate had little or no effect on the activity of these transporters. Interestingly, the capacity of these agents to directly alter dopamine and serotonin uptake, as assessed in vitro by direct application to rat striatal synaptosomes, did not predict their potential to modulate transporter activity following in vivo administration. These findings demonstrate heretofore-unreported differences in the effects of these agents on monoamine transporter function, and a distinction between drug effects after direct application in vitro vs. administration in vivo.
poster:katekite
thread:104261
URL: http://www.dr-bob.org/babble/20020425/msgs/104296.html