Posted by Ritch on June 10, 2002, at 23:43:05
In reply to Re: Trimipramine= no sleep! » Ritch, posted by Chloe on June 10, 2002, at 20:31:48
> Did keeping yourself up let you sleep in? Never works for me. I try to never go to bed before 11pm, if I have no ami, I am always awake before sunrise. Sleep is work without ami. But, I was getting a bit tolerant to ami sedative effects at 20 mgs, but I was scared to increase, because of the negative mood affect it can have. I get a really short unpredictable fuse...That's why I thought trimiprimine would be good. No substancial NE reuptake, and some DA.
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> Well, I think I have some EPS. When I awoke this am, my teeth were loose from clenching. And my tongue really hasn't stopped going since I started trimip. So, with the EPS, total inability to sleep, severe restlessness, and anxiety, I aborted mission last night. I took just 10 mgs of ami and it was a God send. I slept! It was like getting an old friend back.
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> But I am wondering how much off my bad experience with trimip was ami withdrawal? I probably should have tapered, but I just assumed, and wasn't instructed otherwise, I could substitute one TCA for the other. Maybe all the sweating and foggy head on that first day was just withdrawal? But from all I have read, Trimip is supposed to be very sedating, in the same class of doxepin and ami. But 25 mg of trimip wasn't enough to cover the lack of 20 mg of ami, clearly.
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> Could you relate in your experience the difference betweeen Doxepin and Ami. Do you think dox. would be less likely to cause anger outburst at low doses? Is it less or more sedating? How about dry mouth, constipation, wt gain, etc. Would you mind comparing the two for me? If you have done this before, could you send me to the sight? I am just wondering if dox may have less AD punch at low doses like 25 mgs than ami, but same sedative or hypnotic, anxiety effect.
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> Mucho thanks,
> And I really hope you conquered your early am awakening.
> ChloeYep, it worked! There is something that I have been noticing about my seasonal depressions.. I start getting sleepier earlier in the evening and that tends to get a tiny bit earlier every night (it is like an automotive ignition timing becoming "retarded"). Until it reaches the point where my sleep gets "broken" in the early morning (usually around 4-5am. I wake up and I have a hell of a time trying to get back to sleep. Then usually around 8am (three-four hrs later), I get very very tired and fall off and wind up sleeping till noon if I don't have other stuff to do. I wasn't staying up so I could "sleep in", I stayed up late so my sleep wouldn't be "broken up", so I *wouldn't* sleep in. When I have hypomania in the spring and fall, it reverses (the "timing" starts to advance) I notice having a little trouble getting to sleep, and just springing out of bed in the mornings after five or six hours sleep fully refreshed. So, anyhow I think a mild stimulant a few hours before bedtime sets up a blood sugar *crash* right at the time I want it (just a theory).
Well, if you had any EPS from the trimip., you might as well write it off! Doxepin and amitriptyline, hmmm. Doxepin is more sedating, definitely. Less robust antidepressant effect, however. Honestly, I don't think you would benefit much from switching from amitrip. to doxepin. If your pdoc likes the idea of you taking doxepin instead-go for it and see, you never know YMWV. So, I guess you could say that it (doxepin) would have less AD punch, and would be a stronger hypnotic. I just can't stand super sedative meds, though, yuck.
Mitch
poster:Ritch
thread:108844
URL: http://www.dr-bob.org/babble/20020609/msgs/109433.html