Posted by Shawn. T. on July 11, 2002, at 4:35:22
In reply to Re: Some antidepressant theory, posted by cybercafe on July 11, 2002, at 1:49:39
I wouldn't think that there would be a down regulation of say 5-HT1a receptors because of 5-HT2 blockade, but I will research this for you tomorrow. Thank you for bringing that up. As for 5-HT2a, I can't find the studies that you are referring to (I'm not looking hard enough). Could you please point me to them?
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=7364595
This study suggests that 5-HT2 antagonists block dopamaine release in the medial prefrontal cortex:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=16329960
This one suggests that 5-HT2 and 5-HT2a antagonists attenuate the stimulus effects of cocaine:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=16404130
More on M,100,907 which is a potent 5-HT2 receptor antagonist
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=1986311
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=8171765
I think that this study will interest you:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=24790086
5-HT3 does modulate the firing of mesolimbic dopaminergic cell bodies; thank you for pointing that out. Rats cannot discriminate substances that activate 5-HT3, however. Its antagonisation can help block pain, enhance cognitive functions, and may have anxiolytic actions in some, but not all rodent and primate models of anxiety. With regards to constipation, I've personally found that Wellbutrin and Remeron offset each other when it comes to that, although YMMV. 5-HT4 activation has been shown to increase striatal dopamine release by the way; we both win there.http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=25023352
And finally, here's my new favorite study, which could further help explain 5-HT2's effects on anxiety. http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=11719015
As for Remeron, it has been shown to decrease stress induced increase of extracellular release of cortical dopamine and norepinephrine output. I believe the 5-HT2 receptors are involved in this, and it also implies a cortisol reducing effect of the drug I believe. Furthermore, Remeron increases dopamine transmission in the frontocortical region and norepinephrine transmission in the corticolimbic region. I believe that 5-HT2 actually modulates dopamine and norepinephrine activity. It seems to not only increase them but to also prevent stress induced spikes in their levels. I'm still convinced that 5-HT2 antagonists are good. I shall have to compile a list of evidence for this.
You are correct in stating that Remeron is not a wonderdrug. I do believe that either Remeron or Wellbutrin is the most effective drug currently available for antidepressant treatment. Call me biased, but I have previously denied psychiatrist's attempts to put me on Zoloft, Neurontin, and Trazadone. I also did not suggest the Remeron augmentation to Wellbutrin, my current pdoc did.
poster:Shawn. T.
thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112019.html