Posted by cybercafe on July 11, 2002, at 9:24:11
In reply to Re: Some antidepressant theory, posted by Shawn. T. on July 11, 2002, at 7:04:01
> With regards to CRF-Antagonist antidepressants, they may be closer than you think. I have some information that such drugs may already exist but have not been exploited as antidepressants. Until a drug acting on CRF's is released, I have an idea for a drug cocktail that could beat Remeron hands down. Mix an SSRI with the new potent 5-HT2 antagonist M,100,907. During initial treatment, augment the SSRI with pindolol to decrease the amount of time necessary for the SSRI to kick in. This avoids 5-HT3 antagonism and antihistamine problems. I think that is a wonderful idea. Maybe the improvements in psychiatry are running so slowly because I haven't been around to speed them up.
Why not use something like..... nefazodone (serzone) as a 5TH2 antagonist? ... and if Serzone acts like a SSRI + 5HT2 antagonist, why do people not report it as being very effective?
... yes pindolol seems like a good idea to me....
... hell why not throw in a stimulant while we're at it? ...
poster:cybercafe
thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112032.html