Posted by Sunnely on August 2, 2002, at 20:24:42
In reply to Re: Prozac, Codeine, cyp2d6..CamW or anyone ? » Sunnely, posted by jazzdog on August 2, 2002, at 11:37:13
Bupropion (Wellbutrin), like Prozac and Paxil although not as potent, inhibits the break down (metabolism) of codeine (pro-drug) to morphine (active compound) via CYP2D6. This could lessen the pain-killing (analgesic) effect of acetaminophen + codeine. The combination of acetaminophen + codeine is more popularly known as Tylenol # 2, Tylenol # 3, or Tylenol # 4.
Wellbutrin could also lessen the analgesic effect of oxycodone (pro-drug) as it inhibits oxycodone's break down to oxymorphine (active compound). This drug is more popularly known as Oxycontin.
Wellbutrin could also lessen the analgesic effect of hydrocodone (pro-drug) as it inhibits hydrocodone's break down to hydromorphone (active compound). The combination of acetaminophen + hydrocodone is more popularly known as Vicodin.
The following drugs inhibit the enzyme CYP2D6 and may lessen the analgesic effect of codeine:
Potent CYP2D6 inhibitors: cimetidine (Tagamet), fluoxetine (Prozac), paroxetine (Paxil), quinidine (Quinaglute), ritonavir (Norvir).
Less potent CYP2D6 inhibitors: amiodarone (Cordarone), cannabionoids, celecoxib (Celebrex), bupropion (Wellbutrin), desipramine (Norpramin), fluphenazine (Prolixin), haloperidol (Haldol), methylphenidate (Ritalin, Concerta, Focalin), moclobemide (Mannerix), propafenone (Rhythmol), ranitidine (Zantac), sertraline (Zoloft), thioridazine (Mellaril), ticlopidine (Ticlid), venlafaxine (Effexor), vinblastine (Velban). NOTE: Some of these drugs may not lead to clinically significant interaction with codeine.
It does not appear that codeine interferes with the break down of Wellbutrin.
> Hi Sunnely -
>
> I'm currently taking tylenol with codeine for hip bursitis, and am in week four of a Wellbutrin trial. Do you happen to know if Wellbutrin and codeine also act against one another?
>
> Thanks, Jane
poster:Sunnely
thread:114651
URL: http://www.dr-bob.org/babble/20020731/msgs/114996.html