Posted by Larry Hoover on November 7, 2002, at 20:21:13
In reply to fish oil counters weight gain? » mvn_on, posted by babs on November 7, 2002, at 17:14:48
In direct answer to the subject line, yes it does, but only under certain conditions.
A high carbohydrate low-fat diet causes the liver and cells called adipocytes to create fat from carbohydrates, in a process called de novo lipogenesis. That conversion can be higher than 75%, according to recently published experiments.
The long-chain omega-3 fatty acids in fish oil change a number of things which work together to retard the accumulation of fat in your tissues. These include improving insulin-sensitivity (and thereby lowering insulin response to carb intake), and reducing circulating levels of blood triglycerides. Fish oil changes the way your body uses fat, promoting its use for energy now, rather than storing it for later.
One important extra bit is the necessity to get enough exercise to induce deep aerobic respiration. In other words, break a sweat, at least once a day. There is some evidence that this helps muscle cells in retaining insulin sensitivity, which induces them to burn fat.
EMBO Rep 2001 Apr;2(4):282-6
Mechanisms of nutritional and hormonal regulation of lipogenesis.Kersten S.
Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands. sander.kersten@staff.nutepi.wau.nl
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity.
poster:Larry Hoover
thread:125809
URL: http://www.dr-bob.org/babble/20021101/msgs/126892.html