Posted by Larry Hoover on December 17, 2002, at 16:29:56
In reply to Does ibuprofen (Advil) really interact with Xanax?, posted by Aadika on December 17, 2002, at 15:23:33
> Hopefully someone can answer this question for me soon, but if not, I suppose I'll just have to find out for myself.
>
> Oh, one other thing-- I could have sworn I read somewhere that naproxen (Aleve / Naprosyn) potentiates Klonopin. Anyone know if this is true? I've looked all over the appallingly incomplete p450 enzyme sites I've come across and have found no mention of either of these two interactions, but based entirely on anecdotal evidence, I wonder if this is true...
>
> Thanks in advance,
>
> ~ AadikaThe tables I have studied show that ibuprofen and naproxen are both substracts of CYP2C9, whereas both alprazolam (Xanax) and clonazepam (Klonopin) are substrates of CYP3A4. There should be no interaction of any kind between either of naproxen and ibuprofen with either of Xanax or Klonopin. Grapefruit juice inhibits 3A4, as does fluvoxamine (Luvox) and nefazedone (Serzone). The latter is a profound inhibitor of 3A4.
poster:Larry Hoover
thread:132188
URL: http://www.dr-bob.org/babble/20021217/msgs/132200.html