Posted by Larry Hoover on December 19, 2002, at 11:14:43
In reply to Re: Does ibuprofen (Advil) really interact with Xanax? » Larry Hoover, posted by Aadika on December 17, 2002, at 16:39:50
> Thanks a lot-- I knew about the 3A4 interactions, but glad to hear that there are no worries regarding the possible interactions I inquired about. In fact, the only reason I asked was because I believe I've read about naproxen having a potentiating effect on clonazepam (which I mentioned in my last post), and I've read some threads on this board that were related to the interaction between alprazolam and ibuprofen.
>Perhaps there's a need to look at terminology a little bit. Interaction is usually used in the context of one drug changing the kinetics of another. That is to say, the normal metabolic processing of a drug is affected by the presence of another. There are other ways that drug combinations act, however. They might be called additive effects, or synergistic effects, but they are not, strictly speaking, interactions. There is an additive effect of ibuprofen and alprazolam. The following article demonstrates that. You'll need Adobe Acrobat to view it.
http://www.biomed.cas.cz/physiolres/2002/issue2/pdf/dolezal.pdf
> ~ Aadika
poster:Larry Hoover
thread:132188
URL: http://www.dr-bob.org/babble/20021217/msgs/132487.html