Posted by JohnL on March 13, 2003, at 5:27:32
In reply to is ZYPREXA a serotonin agonist or antagonist????, posted by ace on March 12, 2003, at 0:16:35
I'm not sure how the agonist or antagonist thing is all that important. All that really counts is how it makes you feel when you try it.
Regardless of how the drug actually works, clinical studies have shown that Zyprexa significantly elevates serotonin, norepinephrine, and dopamine levels. This is most pronounced when combined with Prozac. How exactly this happens...whether it be agonism or antagonism...I don't know and don't care. I like the way it helps my mood, and that's the main thing I care about.
> I have heard conflicting reports on this. Most people think of the AP's as dopamine/serotonin antagonists. I believe they are all dopamine antagonists - which is helpful for severe OCD.
>
> But with regard to serotonin some people say they are serotonin antagonists. others serotonin agonists.]
>
> Even Toby, a neurologist and psychiatrist who used to post in the early days of this site, stated, "zyprexa causes and all-around boosting of serotonin"
>
> So, what is it. Who knows its affinity for each serotonin receptor? Is their both going on here??
>
>
> Thanks,
> Ace.
poster:JohnL
thread:208300
URL: http://www.dr-bob.org/babble/20030310/msgs/208679.html