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Re: Is Zyprexa a serotonin agonist or antagonist? » cybercafe

Posted by zeugma on March 29, 2003, at 16:20:11

In reply to Re: Is Zyprexa a serotonin agonist or antagonist?, posted by cybercafe on March 29, 2003, at 2:14:58

> > 1A agonism, as provided by buspirone or the eagerly-awaited gepirone, is pretty cool.
> >
> > 2A antagonism is nothing to complain about either, though I'd hesitate to take an AP solely for that effect, there's plenty of other ways to get it:
> >
> > e.g. Serzone and Remeron, or some of the much-maligned old tricyclics: http://www.psychotropical.com/notes/628.html
> >
> >
>
> ummm.. in my case, i havn't heard any mood stabilizing effects of serzone or remeron, so they're not appropriate
>
> in ace's case, they would be contraindicated with an MAOI

I would be very wary of mixing an AP, even a new atypical one, with an MAOI. The side effects of either are potentially so serious- hypertensive crisis and serotonin syndrome for the one, irreversible TD for the other- that even if not absolutely contraindicated (I have no idea), it's just asking for neurological disaster.
>
> i really wish they had gotten pure 5HT2A antagonist out (ritanserin, ketanserin, etc) but i hear they didnt' do well in trials
> so maybe they wouldn't be that good after all

Seems that 5HT2A by itself just helps with sleep rhythms (isn't that what ritanserin is for?) This can be very helpful for depressed people but I doubt it's enough to remit depression by itself.


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URL: http://www.dr-bob.org/babble/20030329/msgs/214113.html