Posted by zeugma on March 30, 2003, at 20:45:51
In reply to Re: Is Zyprexa a serotonin agonist or antagonist?, posted by cybercafe on March 30, 2003, at 19:31:03
> > > i felt great on parnate + zyprexa ... i know they are both serious medications... but i don't see a reason to believe that the risks increase when they are taken together
> > >
> > That's good to hear. I believe you have been dx with ADD? Was the Parnate helpful for this disorder?
>
> i'd say no.. but it was a lot better than feeling depressed.
>
The reason I asked was because Parnate is often called "amphetamine-like" and it has been claimed that it metabolizes to amphetamines (there was a recent controversy about this on this board). I have severe inattentive ADD and am interested in any possible meds for this condition; I know MAOI's are used as a 'last-resort' option for ADD sometimes and Parnate seems like the logical choice.
> > > > Seems that 5HT2A by itself just helps with sleep rhythms (isn't that what ritanserin is for?) This can be very helpful for depressed people but I doubt it's enough to remit depression by itself.
> > >
> > > i don't know anything about ritanserin ... where did you hear about it's use in sleep rhythms?
> > >
> >
> > Ritanserin increases slow-wave sleep: http://link.springer-ny.com/link/service/journals/00213/contents/00/00633/s002130000633cl
> >
> > It appears from this study that 5HT-2A antagonism won't help with anxiety or depression but can help with specific sleep problems.
>
> hmmm.. i notice an antidepressant effect after i take 2.5 mg zyprexa ... maybe it's a placebo effect... or maybe when 5HT2A receptors are blocked there's enough to hit 5HT1A and other good receptors ... who knows
>Zyprexa is probably helping with your depression as well as any other problems. Drug 'classification' to a large degree is arbitrary...in fact antipsychotics have been shown to have efficacy in depression. A drug like lithium can help people with unipolar depression, too, even though it's classed as a mood stabilizer.
poster:zeugma
thread:213675
URL: http://www.dr-bob.org/babble/20030329/msgs/214577.html