Posted by samplemethod on June 23, 2003, at 7:54:03
In reply to Re: adapton or DLPA experiences or knowledge? » avid abulia, posted by Larry Hoover on June 15, 2003, at 18:48:00
Can someone please give evidence that it is actually the d-form (and not the l-form) of phenylalanine that is an inhibitor of enkephalin breakdown?
Cheers
> > adapton is a french drug, an extract of a fish of the genus *garum*, which contains peptides converted into endorphins once in the brain. it is cheap to import, and has been shown to be effective in acute stress and in inattention, but little research has been done regarding effects on depression or other disorders.
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> I'll look into this, as I'm curious.
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> > DLPA is a mixture of the d- and l- isoforms of the amino acid phenylalanine. l-phenylalanine can be converted into the trace amine phenylethylamine, which is both a naturally occurring amine protected by MAO-B inhibitions, as well as a metabolite of the mixed-MAO inhibitor Nardil. it can also be converted to the non-essential amino acid tyrosine, which is necessary to produce dopamine, adrenaline, and noradrenaline, as well as thyroxine. the d-phenylalanine is an inhibitor of enkephalin breakdown, and DLPA has had clinical studies showing it`s efficacy as an antidepressant and also for inattention and chronic pain, BUT as it contains a d-isoform of an amino acid, i am wondering if anyone knows if it has long-term toxicity? i have been unable to find any indications one way or the other.
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> There is no reason to think that d-aminos are toxic. Fermentation of all sorts produces them. About 8% of the aminos in beer are d-isomers, for example.
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> I have seen no evidence of any adverse effects of d-phenylalanine. Quite the contrary, in fact, as your own inquiry has demonstrated.
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> > as i am unable to take either conventional antidepressants or conventional stimulants because of a seizure disorder, and i have a chronic though episodic pain disorder with no real treatment available, i am wondering if anyone here has tried these, what their experiences were, and if they think potential benefits outweigh potential risks in my situation.
> >
> > ~AA
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> I like the effect of DLPA in my brain. Given your health concerns, I'd recommend that you "start low, and go slow", i.e. small initial dose (500 mg?), and small increases over time.
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> Lar
poster:samplemethod
thread:234152
URL: http://www.dr-bob.org/babble/20030619/msgs/236264.html