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Re: 5H-T 2A blockers and sleepiness » jemma

Posted by zeugma on August 1, 2003, at 19:44:49

In reply to Re: please define derealization, posted by jemma on August 1, 2003, at 16:18:31

Jemma,

As far as I know, blocking 5HT-2a receptors CAUSES sleepiness, as evidenced by the drugs that have the highest degrees of 5HT-2a antagonism: trazodone, amitriptyline, and of course newer neuroleptics like Zyprexa and Seroquel. 5HT-2a antagonism is not only supposed to cause sleepiness, it is said to improve sleep quality as well (which is actually more important). I attribute a lot of the improvement in my ability to get restful sleep to the fact that nortriptyline also blocks this receptor.


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