Posted by Ame Sans Vie on September 21, 2003, at 0:53:24
In reply to Ame s Vie, serious about tramadol, few Q's » Ame Sans Vie, posted by temoigneur on September 18, 2003, at 1:06:19
> Hi Michael great, you give me a wide range of options to keep tolerance at bay.
Just remember to discuss these things with your doctor first! DXM-therapy isn't for everyone -- there are other NMDA antagonists though. Memantine and acamprosate are the two most promising ones apart from DXM (there are many others, but the only ones that immediately come to mind are ketamine and PCP).
> Regarding the Buprenorphine, it's not available up here, except through something called the "Special access program", something your Canadian physician would have to apply for, however I read on the sight that this program was not accepting new applicants right now - if bureaucracy was a cord you could go bungee jumping,
<sigh>... oh well. I may be discontinuing the Ultram and starting Xyrem within a week, depending on whether my pain management doc can persuade Medicaid to cover the ridiculous expense. If I were able to receive Xyrem though, I'm pretty sure I'd stay here. Well... in the U.S. anyway -- not Texas, lol.
> anyway, I'm serious about trying tramadol, I'm in pain,(with the OCD and anxiety I am taking a course I've already taken in college just so I won't go crazy, it's aweful, and my family is so supportive, situationally it doesn't get too much better, well, there's some things beyond our control, but.. I was wondering how long you have been been on Tramadol, and if you sense tolerance developing, and if not, do you know of anyone else, through personal contacts, or studies that have the same experience, or is keeping tolerance of Tramadol at bay with DMX a rare phenomina.
I'm not absolutely sure how long I've been taking the tramadol... about 14 weeks, I suppose. I've noticed no tolerance whatsoever to the antidepressant-antiobsessional effects, though the pleasant opioid effect quickly wears off. Most medical sources comment that tramadol causes a mild tolerance and moderate dependence, but of course they're talking about its use as an analgesic. The case reports of tramadol in depression/OCD treatment that I initially used to convince my pdoc to prescribe it for me never mentioned tolerance. It seemed that the dose always leveled off at the 300-400mg range. But as for the DXM, I really can't say much of anything as there hasn't been a whole lot of research (if any) into using it for this purpose. I've never come across a case report either. But the abilities of memantine and acamprosate to delay or prevent tolerance is fairly well-documented, and the mechanism of action is the same. It's only at disassociative recreational doses (depending on body weight, anywhere from perhaps 400mg-2 grams) that DXM has any significant effects in other areas of the brain, primarily at sigma receptors, where PCP is also quite active.
>Michael thank you so much for your responses you're so kind.
>
> All the best, and I hope things keep going brilliantly, BenNo problem at all, and good luck to you! Let me know how things unravel. :-)
poster:Ame Sans Vie
thread:259342
URL: http://www.dr-bob.org/babble/20030917/msgs/262089.html