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Parnate can be activating at high dose » Mookie

Posted by DSCH on September 28, 2003, at 8:00:58

In reply to Re: ADD/SocialPhobia/OCD, posted by Mookie on September 27, 2003, at 12:10:10

> Thank you all for your ideas and suggestions.
> I think I will talk to my pdoc about parnate. I just fear losing some of the SP, anxiety, and OCD benefits of the nardil.
>
> Mookie

OK, I can say where I picked this impression up about Parnate (tranylcypromine) being activating: Perrine's book (gee, I'm getting predictable these days I think).

Let me quote...

"Tranylcypromine can be seen either as a modification of phenethylamine [sic?] or as an amphetamine with the side chain cyclized into a cyclopropane ring; in larger doses than those used to treat depression, it can cause psychomotor stimulation, and the development of dependence occasionally has been reported." [no references cited]

Perrine, "The Chemistry of Mind-Altering Drugs...", American Chemical Society, 1996, p. 234.

Looking at the structural representations, phenelzine (Nardil) also appears somewhat similar to the amphetamines, but Perrine makes no mention of stimulant properties.

It's unfortunate IMO that he has not treated the MAOIs to as much discussion as he has the tricyclics.

You will probably want to be careful about how you broach the subject of switching to high-dose Parnate with your pdoc.


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