Posted by MARKED on January 19, 2004, at 2:30:32
In reply to Re: MOCLOBEMIDE with TRILEPTAL ?? Dr. BOB HELP, posted by Karen Moore on January 17, 2004, at 22:17:39
ok, i am very aware of what you are saying, but i AS YET (would like to see your information) haven't seen any proof that specifically MOCLOBEMIDE with TRILEPTAL contraindicates one another. I have read about Tegretol and MAIO's. But Moclo... is a RIMA, and Trileptal is not Tegretol (although similar, its effects can be very different with other drugs). I don't accept that people think if an apple looks orange that it will taste like an orange (not intended to be critism at you, but rather info that is released to the public).
I am not sure if everyone is aware, but Moclobemide is a RIMA (reversable mono-amide oxidase inhibitor, specifically reversable A blocker (but partially reversable B blocker), and not at all a MAOI (wich are not reversable).
But my question is more to do with the RIMA's and their safety (which genarally i'd think is much safer than MAOI's). Also, because Trileptal has effects on the liver, this causes other drug interraction to be speed up, and metabolised. Also i'd say a controlled diet would be needed, because of the salt reduction effects, and possible increased heartbeat.Also there is no specific DIRECT clinical info that i can find from either manufactures or other studies. There is though a new drug that is coming out very soon, that i have read testing on (which surprisingly seems like this very combination I am stating).
I'd like to see, (but appreciate people's views) more proof on specifically what i'm asking, or people that have tried this combination (obviously ethically, and under supervision of their psychdocs). My doc just plainly says NOPE they are not compatible, and I want some proof..which no one can slightly show me as yet.
Also I lately have contemplated.. (but this combination, surely would be very potent, although much more effective at lower doses, and minimal side effects) Brofaromine & Trileptal (this combination if studied would be what i feel very potentially a good stabilizer of this illness, as yet no studies have been done (although I suspect drug companies are starting to combine mixes like this to bring out new drugs.....smart huh? save money, make millions more)
Mark
> I researched this possibility just a month ago. There's a "theoretical" contraindiction for the two based on the observation that Tegretol
> (and thus Trileptal) is structurally very similar to the TCAs, which in combination with traditional older MAOIs has meant trouble (hypertensive crisis I suspect).
poster:MARKED
thread:302044
URL: http://www.dr-bob.org/babble/20040118/msgs/302590.html