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Re: Buspar mechanism of action

Posted by chess on February 12, 2004, at 22:43:24

In reply to Re: Buspar mechanism of action, posted by linkadge on February 12, 2004, at 10:20:29

I've read that Buspar actually reduces anxiety because it eventually desensitizes the 5ht1a receptor over a period of time of activating it, and this desensitization ends up promoting serotonin release which then over time down-regulates the 5ht2a receptor and thus reduces anxiety.

Does that sound correct?

Or is Linkadge correct that Buspar basically reduces anxiety because it activates the 5ht1a receptor which decreaes serotonin release which thus reduces serotonin available at the 2a receptor?


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