Posted by chess on February 13, 2004, at 10:10:17
In reply to Re: Buspar mechanism of action, posted by scott-d-o on February 12, 2004, at 23:25:44
The interesting point is that it takes Buspar around 4 weeks for its therapeutic action to take effect.
So what it initially does (full agonist at 5-HT1a autoreceptors and a partial agonist at postsynaptic 5-HT1a receptors) is not what I'm asking about specifically, but rather what effect it has caused after 4 weeks is the question, which is why I remarked and asked for confirmation about Buspar reducing anxiety because over time (around 4 weeks) it eventually desensitizes the 5ht1a autoreceptor which then causes more serotonin to be released which then over time down-regulates the postsynaptic 5ht2a receptor and thus reduces anxiety.
I understand why some people say "just take it", but if buspar's effect is due primarily to it's enhancement of serotonin release after 4 weeks then it seems to me that the SSRIs are doing the same thing, so why not just take an SSRI?
poster:chess
thread:312027
URL: http://www.dr-bob.org/babble/20040210/msgs/312804.html