Posted by Sad Panda on March 20, 2004, at 3:19:18
In reply to Re: Improving Restorative Sleep, posted by King Vultan on March 19, 2004, at 15:38:28
> > Hello,
> >
> > I have no problem with falling asleep, staying asleep, or apnea, yet I have the lifelong handicap of waking up exhausted and staying that way till late afternoon.
> >
> > I have tried the SSRIs, MAOIs, Z-drugs, Benzos -- mostly for APD -- and nothing has helped with restorative sleep.
> >
> > Are there any meds which can help with restorative sleep? Thanks.
> >
> > --Jay
> >
>
> Trimipramine (Surmontil), which is a sedating TCA, seems to have some unique sleep properties. It may be worth a try.
>
> Todd
>Drugs that are H1 blockers + 5-HT2A blockers tend to induce quality sleep. Trimipramine is the most potent of the 5-HT2A blocking TCA's, Doxepin, Amitriptyline & Nortriptyline are pretty good too & can be mixed with SSRI's. Clomipramine is also good but is strongly serotoninergic. A good drug by itself, but not to be mixed with SSRI's. Imipramine & Desipramine are weak & very weak H1 & 5-HT2A blockers. I suspect it's this difference that makes Clomipramine & Amitriptyline superior to Imipramine as stand alone AD's. I take Remeron myself with Effexor.
Cheers,
Panda.
poster:Sad Panda
thread:326121
URL: http://www.dr-bob.org/babble/20040319/msgs/326350.html