Posted by rod on March 24, 2004, at 5:19:20
In reply to Re: Dopamine Agonists Mirapex » bertill33, posted by Ame Sans Vie on March 23, 2004, at 9:42:26
I think amantadine is pretty useless for mood disorders. My doctor has a double blind placebo controlled study of Amantadine for depression which showed its not better than placebo (I didnt found this one at pubmed). But I am sure, its somewhat working for a small subgroup of people. It increases synthesis of dopamine (via NMDA blockade) but also reduces Serotonin synthesis (also via NMDA blockade), inhibits reuptake and increases release of dopamine. All 1-aminoadamantanes (Memantine, Amantadine etc.) noncompetitively inhibit MAO activity (I think A+B, this wasnt specified in the abstract).
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6891223
And actually I am taking Amantadine, but did *not* notice any positive effect on mood. At the beginning it gave me some nice freshness to my forebrain, but this subsided after a few days. And turned out to be somewhat a downer to me, like a mood stabiliser. I am currently tapering down, and notice that I am actually feeling better now.
But you wont know, until you try it. I did take it because I have antibodies for Borna Disease Virus in me.Roland
poster:rod
thread:327293
URL: http://www.dr-bob.org/babble/20040319/msgs/327626.html