Posted by zeugma on June 3, 2004, at 18:15:14
In reply to Would strattera treat depression and ADD??, posted by TenMan on June 3, 2004, at 17:34:03
> For those who have experience with strattera did it have an antidepressant effect? I have anergic depression along with inattention and have been looking for something to replace my wellbutrin. It just isn't cutting it.
>
> Also does anyone have any idea why many people report strattera makes them drowsy? By what mechanism does this take place?1st. Yes, it has an antidepressant effect. It also helps the ability to focus.
2nd. The speculated mechanism for drowsiness is stimulation of alpha-1 and -2 adrenergic receptors. The flaw in this explanation is that it causes more fatigue than nortriptyline, which is also a NE transporter inhibitor, and is more sedating than Strattera to boot (sedation as in increasing the propensity to sleep). This is a major limiting factor in the long-term usage of this medication, particularily for inattentive types, who are prone to suffer from fatigue anyway.
>
> Thanks
poster:zeugma
thread:353502
URL: http://www.dr-bob.org/babble/20040602/msgs/353514.html