Posted by King Vultan on June 3, 2004, at 20:23:45
In reply to Would strattera treat depression and ADD??, posted by TenMan on June 3, 2004, at 17:34:03
> For those who have experience with strattera did it have an antidepressant effect? I have anergic depression along with inattention and have been looking for something to replace my wellbutrin. It just isn't cutting it.
>
Yes, it does have an antidepressant effect similar to other selective norepinephrine reuptake inhibitors I have tried, including nortriptyline, desipramine, and Vivactil (protriptyline).
> Also does anyone have any idea why many people report strattera makes them drowsy? By what mechanism does this take place?
>
> Thanks
It is kind of strange, but I believe it is just a characteristic of the molecule, in the same way that Paxil is sedating compared to other SSRIs despite the fact that this is completely unobvious from looking at its pharmacology and receptor blockades. The tricyclics desipramine and Vivactil both have histamine blockades that Strattera apparently completely lacks, and I found neither of them to cause the drowsiness that Strattera did. Speaking of Vivactil, this drug is easily the most stimulating of the tricyclics, but again, there is absolutely no explanation for this looking at its pharmacological profile. It is another case where it is just an intrinsic ability of the molecule.Todd
poster:King Vultan
thread:353502
URL: http://www.dr-bob.org/babble/20040602/msgs/353531.html