Posted by zeebop on August 16, 2004, at 5:55:29
In reply to Re: Questions about long term TCA (esp desipramine), posted by linkadge on August 15, 2004, at 15:44:52
> I think there is definately more long term experience with TCA's than there is with the newer AD's ie SSri's etc.
>
> Generally, I believe that TCA's arguably are the gold standard of AD medication. It is true that you generally hear less about AD poop out.
>
> I think that because of their broad spectrum activity they tend to induce less apathy. I knew of a few people who had been on TCA's for 20+ years and were urged to change to a newer AD by their docotors in hopes of reducing some of the potential hazards that TCA's can impose. After a full trial of several of the newer AD's the patients confess that the newer AD's have specific limitations and seem to work only 'half as well' as their older medication.
>
> one thing that I believe owes to the increased effectivness of the older TCA's is the fact that they are generally better at activating the prefrontal cortex. The SSRi's can lead to prefrontal hypofunction over the course of months.
>
> Linkadge
Hi,
I cannot agree more :
I took all 6 SSRis,Traz,Nefaz,Effex,Wellbut,Remer,Moclobemide,Tianeptine,Viloxazine,Reboxetine,Milnacipran..and all other "new" AD'd
I also took TCA's like Imipramine,Desipramine,Amitriptyline,Nortriptyilne,Maprotiline....etc and I think that Tca's are much more effective than all those new ones,especially for me (in this order) : Imipramine,Amitriptyline,Maprotiline and Nortriptyline
TCA's side effects diminsh quoqly with time,and they have instant relief from insomnia and anxiety,and most are effective in ADD,and unlike the SSRIs,are energizing+no sexual effects (Except Anafranil which is the only one that isvery similar to Effex and SSRis)Unfortunatly, I gained weight in ALL of AD's,but on TCA's weight gain is dose- related...but WG on newer AD's is accumelative and has no way of stopping it except terminatind the drug...so the soulotion to weight gain ? :
SELEGILINE : it is the most underated AD on the planet : in 5-10 mg it gives a very rapid response (increase in energy,motivation,positivity,concentration ) and NO APATHY OR WEIGHT GAIN...and if it makes you alittle anxious you could add a low- dose BZ,like Bromazepam (Lexotan)......
This is my limited experience I'll be glad to recieve commentsAll the best
poster:zeebop
thread:377967
URL: http://www.dr-bob.org/babble/20040811/msgs/378144.html