Posted by chemist on August 17, 2004, at 21:07:15
In reply to Re: input? panda, vultan, sls, larry, others...?, posted by zeugma on August 17, 2004, at 20:41:10
hello, zeugma - thanks for the kind words, and i apologize for not including your nom-de-plume in the tagline....i was just replying to one of your posts down the way, in re: stimulant/benzo combinations.....thank you much for the info in re: the TCAs. i can only read so much of this stuff in the literature before going to real-life adventures.....your point about one person's solution being another's problem is well-put, and i am sensing that the TCAs are indeed more reactive on an individual basis than, say, the SSRIs....in any event, thanks again for the info, and thank you for the welcome back.....be well, chemist
> hi chemist (and it's great to have you back):
>
> the TCA's are pharmacologically complex drugs, and have many variations both in how they are metabolized and in their pharmacodynamic effects. For example, it seems that the metabolites of all the TCA's (both tertiary and secondary amine) get progressively more selective for NE vs. 5-HT reuptake and less sedating and side-effect-ridden (for example the hydroxylated metabolite of nortriptyline is about 18 times less anti-muscarinic than its parent form). since the enzyme responsible is the polymorphic 2D6 this leads to great variation in terms of how nasty (to put it bluntly) the drug is perceived to be. Also, as someone once said, one person's side effect is another person's good night's sleep; I have found this to be true of nortriptyline, and I have no trouble at all running several miles after administration, then going to sleep several hours later.
>
> others will have more enlightening things to say.
>
> -z
poster:chemist
thread:377967
URL: http://www.dr-bob.org/babble/20040817/msgs/378914.html