Posted by SLS on August 20, 2004, at 17:24:08
In reply to Re: Shouldn't there be a limit to this, tried rTMS » SLS, posted by iris2 on August 19, 2004, at 10:49:49
Hi Pest.
:-)
> I do not understand NE/5-Ht so well. Can you elaborate or simply compare it with similar drugs so I can understand it better? Perhaps a link if you have one on the top of your head or under your arm! I know I am a pest.
This will have to be short - sorry. I have a date with the circus.
NE = norepinephrine
5-HT = serotoninSome drugs, like the SSRIs (Prozac, Zoloft, Paxil, Luvox, Celexa, Lexapro), only work on one neurotransmitter - in this case, serotonin. Others work primarily on norepinephrine (desipramine, nortriptyline, reboxetine, maprotiline). Some work on both. Most of the tricyclics and Effexor inhibit the reuptake of both 5-HT and NE, but not always equally. Effexor, in particular, is much more potent on 5-HT than NE. Cymbalta is still biased towards 5-HT, but not as much. It is more balanced. I guess you could say that Cymbalta is a better-balanced version of Effexor. It *might* thus produce an antidepressant effect similar to high dosages of Effexor, but with milder side effects - especially those involving sexual function and apathy. We'll have to see about that.
In general, it is becoming apparant that drugs that work on multiple neurotransmitters are more effective than those that are selective to only one. Effexor, for example, seems to get more people well, gets each person more well, and poops-out less often than the SSRIs.
> Thanks for being you,
That is the nicest thing that anyone can ever say to me. Thank you.
Ditto.
Please don't ever be reluctant to ask questions of anyone here. It's what makes this place work. My explanation was overly simplified, so don't be afraid to dig deeper. Most drugs, even the "selective" ones, are biologically active at sites other than the ones considered to be primary. It is difficult to conclude which properties are essential, and which are unnecessary or undesirable.
- Scott
poster:SLS
thread:378449
URL: http://www.dr-bob.org/babble/20040817/msgs/380071.html