Posted by Larry Hoover on August 21, 2004, at 21:03:11
In reply to Re: Sleeping drugs » Larry Hoover, posted by jlbl2l on August 21, 2004, at 20:23:30
> What more is there to say, do I not understand your post correctly? benzodizepines suppress slow wave activity (delta waves..) and increase stage 2 sleep (beta) that is what these studies say.
I apologize for posting in such a fragmented way. My mind was elsewhere, and I guess I assumed you could read my mind?
Quick synopsis...
In my first post to this thread, I said:
"I'm sorry, but that is quite false. In "normal" people, benzos block deep sleep, but in those with primary insomnia, quite the opposite occurs."I backed that up with a study of primary insomniacs, excerpted here:
"Transitions between sleep stages were profoundly influenced by the time of the night and by the time since the last change of sleep stage. Temazepam reduced the time spent awake. This effect could be attributed to four mechanisms: (1) transition to "deeper" sleep was facilitated, (2) transition to "lighter" sleep was inhibited, (3) regardless of sleep stage, the transition to wake state was inhibited, and (4) return to sleep was facilitated."Which I intended to contrast with this other study in healthy people, which found:
"Benzodiazepine hypnotics increase NREM sleep and alter its EEG by reducing delta (0.3-3 Hz) and increasing sigma (12-15 Hz) and beta (15-23 Hz) activity. "I forgot to include that one in the first post. Then, I just added the following, which was incomplete. I've added the words I left out, which was due to my rushed response:
"I hope you're not looking for an essay. Specific benzos, the ones that are hypnotics, most certainly do increase slow wave activity *in primary insomnics*. I gave a single example, as modest proof of the alternative to your generalizations."All I meant to say all along is that there is a population in which the hypnotic benzos have a predictable but paradoxical response.
Sorry for making a mess of things....trying to do too many things at one time.
Lar
poster:Larry Hoover
thread:380051
URL: http://www.dr-bob.org/babble/20040821/msgs/380593.html