Posted by Larry Hoover on August 22, 2004, at 9:06:29
In reply to Re: Sleeping drugs, posted by jlbl2l on August 21, 2004, at 21:36:50
> Larry,
>
> No problem. I understand, basically what your saying is some people react the opposite to those benzos like yourself. one persons nightmare is another person's magic. i get it. most drugs have some people who have the opposite reaction. i just wasnt understanding.That was, like, totally my fault, dude. I was so hectified yesterday, I was totally distractulated. I am humbly grateful for your patience and tolerance.
> i do believe the majority of people aren't like this though. as long as it works for you tho.
>
> all the best,
> jasonI'd go with the majority opinion. ;-)
However, like I said, I was victimized by doctors who wouldn't accept that there even was another case to consider.
There's another aspect to this whole thing, about tolerance. Unlike lorazepam, long-term use (up to 20 years) of temazepam does not seem to (necessarily) create tolerance. Even long-term users had similar responses to temazepam-naive controls.
Lar
Br J Clin Pharmacol. 1997 Sep;44(3):267-75.
A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population.
van Steveninck AL, Wallnofer AE, Schoemaker RC, Pieters MS, Danhof M, van Gerven JM, Cohen AF.
Centre for Human Drug Research, Leiden University Hospital, The Netherlands.
AIMS: The central effects of benzodiazepines may be attenuated after chronic use by changes in pharmacokinetics, pharmacodynamics or both. This attenuation may be influenced by the dosing pattern and the characteristics of the user population. The objectives of this study were to evaluate drug sensitivity in long-term users of temazepam and lorazepam in a clinical population. METHODS: The sensitivity to benzodiazepine effects in chronic users (1-20 years) of lorazepam (n = 14) or temazepam (n = 13) was evaluated in comparison with age and sex matched controls. Drug sensitivity was evaluated by plasma concentration in relation to saccadic eye movement parameters, postural stability and visual analogue scales. RESULTS: Pharmacokinetics of lorazepam and temazepam did not differ between patients and control subjects. Chronic users of lorazepam showed clear evidence of reduced sensitivity, indicated by lack of any pharmacodynamic difference between patients and controls at baseline, when drug concentrations were similar to the peak values attained in the control subjects after administration of 1-2.5 mg of lorazepam. In addition, there was a two- to four fold reduction in the slopes of concentration-effect plots for measures of saccadic eye movements and body sway (all; P < or = 0.01). By contrast, sensitivity in chronic users of temazepam was not different from controls. The difference between the temazepam and the lorazepam group appears to be associated with a more continuous drug exposure in the latter, due to the longer half-life and a more frequent intake of lorazepam. This pattern of use may be partly related to the more anxious personality traits that were observed in the chronic users of lorazepam. CONCLUSIONS: Chronic users of lorazepam show evidence of tolerance to sedative effects in comparison with healthy controls. Tolerance does not occur in chronic users of temazepam. The difference may be related to pharmacological properties, in addition to different patterns of use, associated with psychological factors.
poster:Larry Hoover
thread:380051
URL: http://www.dr-bob.org/babble/20040821/msgs/380769.html