Posted by 4WD on September 12, 2004, at 17:42:09
In reply to Re: glutamate inhibitors, glutamate releasers, posted by 4WD on September 12, 2004, at 17:10:41
> > How is it that two, totally opposite mechanisms of a drug can provide antidepressant properties. Drugs like modafanil cause a release of glutamate and have antidepressant properties. On the other hand, drugs like riluzole reduce glutamate activity and have antidepressant properties.
> >
> > I'm confused
> >
> > Linkadge
>
> I have read that with many (most?) a/d drugs, the antidepressant effect may not be a result of the drug's direct action. It may rather lie in the brain's adaptions elsewhere to the drug. That is, when you take an SSRI, the AD effect may not come from the increased amount of available serotonin but from the brain's making physiological changes elsewhere in response to the increase in serotonin or decrease in reuptake. Neurons are forced to adapt and change in response and an AD effect is the result. This would also explain why serotonin reuptake accelerators (is that reboxetine?)can have the same effect as inhibitors.
Whoops. My mistake. It's tianeptine, not reboxetine, that's a serotonin reuptake accelerator.
>
poster:4WD
thread:389725
URL: http://www.dr-bob.org/babble/20040909/msgs/390057.html