Re: NE-deficient mice lack responses to SSRIs » SLS

Posted by jrbecker on October 19, 2004, at 14:53:02

In reply to Re: NE-deficient mice lack responses to SSRIs, posted by SLS on October 19, 2004, at 11:06:41

> Hi JRB.
>
> Thanks for the citation.
>
> Which, if any, SSRIs do NOT downregulate postsynaptic NE beta receptors?
>
> Thanks.
>
>
> - Scott
in terms of the ssris, perhaps celexa(citalopram) is the only one in the class that doesn't downregulate the NE beta autoreceptors to a great extent. I'm guessing this is b/c celexa has the purest serotonergic effect of all the ssri's. And this is why the study cited earlier found that citalopram was the only one whose antidepressant effect wasn't fully vanquished by disruption of the NE pathway.

i know luvox (fluvoxamine) does downregulate the NE autoreceptors though...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1378371&dopt=Abstract

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NE-deficient mice lack responses to SSRIs jrbecker 10/19/04
Re: NE-deficient mice lack responses to SSRIs SLS 10/19/04
Re: NE-deficient mice lack responses to SSRIs » SLS jrbecker 10/19/04
Re: NE-deficient mice lack responses to SSRIs Dave001 10/19/04
Re: NE-deficient mice lack responses to SSRIs jboud24 10/19/04

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