Posted by Dave001 on October 19, 2004, at 21:05:23
In reply to Re: NE-deficient mice lack responses to SSRIs » SLS, posted by jrbecker on October 19, 2004, at 14:53:02
> > Hi JRB.
> >
> > Thanks for the citation.
> >
> > Which, if any, SSRIs do NOT downregulate postsynaptic NE beta receptors?
> >
> > Thanks.
> >
> >
> > - Scott
>
> in terms of the ssris, perhaps celexa(citalopram) is the only one in the class that doesn't downregulate the NE beta autoreceptors to a great extent. I'm guessing this is b/c celexa has the purest serotonergic effect of all the ssri's. And this is why the study cited earlier found that citalopram was the only one whose antidepressant effect wasn't fully vanquished by disruption of the NE pathway.
>That's interesting, because citalopram (and naturally its optical isomer, escitalopram) is the only SSRI I have found evidence of *not* interfering with nitric oxide (NO). Accordingly, it produces significantly less sexual side-effects than other SSRIs (at least in lab animals). As far as I can tell, the SSRIs (with the exception of citalopram) are non-specific in reducing the expressing the NO synthase (NOS), meaning there is a decrease in neuronal and endothelial NOS, as well as inducible NOS.
Dave
poster:Dave001
thread:404681
URL: http://www.dr-bob.org/babble/20041018/msgs/404933.html