Posted by linkadge on November 3, 2004, at 11:40:28
In reply to Re: Classical Neuroleptics: Dysphoria in pill form!, posted by ed_uk on November 3, 2004, at 10:58:13
Many of the psychadelics act on the 5-ht2a recetpor, being agonists.
THe only problems is that strong 5-ht2a agonism by LSD and others leads to a very rapid downregulation in the 5-ht2a receptors.
If you suddenly introduce a 5-ht2a antagonist (risperidone strong 5-ht2a antagonist) into the picture, the 5ht-2a receptor gets virtually no serotonin, which can create severe states of panic.
Potent 5-ht2a agonism creates feelings of empowerment and "universal understanding"
even a "cosmic contiousness" if you will.But potent 5-ht2a antagonism can lead to feelings of being nonexistant. (often happens at the end of a LSD trip) creating sudden and severe panic.
This is not to even mention messing with the dopamine system.
Linkadge
poster:linkadge
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411068.html