Posted by jboud24 on November 4, 2004, at 9:54:32
In reply to Re: Classical Neuroleptics: Dysphoria in pill form!, posted by Chairman_MAO on November 4, 2004, at 4:29:03
You are right on with the difference in typical versus atypical dissociation constants. I read somewhere in an old University neurobiology text of mine where they were singing the praises of these two 'new and improved' neuroleptics called atypicals. The book went on to discuss different equations on how to calc. dissociation constants, but said that atypicals reduce side-effects by 3 known methods: 2a antagonism, better binding to the limbic vs. striatal brain structures, and in the case of clozapine a weaker dissociation constant.
Later guys,
Justin
poster:jboud24
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411590.html