Posted by SLS on December 6, 2004, at 0:43:29
In reply to Re: GABA transaminase inhibition, posted by ed_uk on December 5, 2004, at 14:59:11
> Hi Ted and Jclint :-)
>
> Jclint summarises the important points...
>
> '- There is little clinical research into Parnate's effeciacy in SA, but quite a lot into Nardil's
> - Parnate is apparently less forgiving in terms of dietary restrictions
> - Parnate generally causes more insomnia than Nardil'.
>
> ........ I have often wondered how important the GABAergic effect of Nardil is in social anxiety. The GABAergic effect of Nardil is *not* the same as a benzodiazepine. Unlike Parnate, Nardil is a GABA transaminase inhibitor which means that it inhibits the breakdown of GABA. In the UK, an anticonvulsant called vigabatrin is available- it is a GABA transaminase inhibitor. Behavioural/psychiatric side effects are very common. Ahhh :-(
>
> Some of the common side effects of vigabatrin are...
>
> drowsiness, fatigue, dizziness, anxiety! aggression, depression and headache. Less common side effects include... psychosis, amnesia, double vision, weight gain! and agitation.
>
> Of course, vigabatrin and Nardil are different drugs but to be honest.... I'm not sure that I want to take a GABA transaminase inhibitor.
>
> Regards,
> Ed.
>
>Vigabatrin can also cause visual field defects that I believe are irreversible.
- Scott
poster:SLS
thread:424658
URL: http://www.dr-bob.org/babble/20041201/msgs/425064.html