Posted by linkadge on December 7, 2004, at 10:14:10
In reply to Re: MAOIs and aggression, posted by ed_uk on December 7, 2004, at 7:41:00
SSRI and tryciclics might not cause the same decreases in 5-htaa levels that MAOI's do.
And you are right, these are antidepressants, and not antiagressive agents. (a) Do they increase agression, (b) does this have any effect on their clinical effect.
What I think is stupid is the forced rat swim test. I can be agressive and yet still depressed.
Ie, I might swim for hours and yet still be depressed. Ie the drug might just prolong swimming by inducing agression. This does not mean the mice are any happier about it.Lithium is interesting. when used as a sole agent, it almost always decreases agression.
It increases overall 5-ht1a/b activity, but decreases serotonin at other receptors.
Ie. SSRI's are terrably blunt tools. Saying this or that is caused by high or low serotonin is stupid because it's really the receptors that determine what serotonin does.
We need a series of potent and selective serotonin agonists, in order to figure out one receptor from the next.
Linkadge
poster:linkadge
thread:425286
URL: http://www.dr-bob.org/babble/20041206/msgs/425683.html