Posted by jerrympls on December 10, 2004, at 18:03:25
In reply to AD Tolerance/Dysthymia, posted by SDW on December 8, 2004, at 17:31:30
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> To anyone who has had an AD poop-out over the course of long-term treatment, or had residual dysthymia/anhedonia while on meds, I am wondering what others might consider doing in my shoes:
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> For the last 2 years I have had a moderate chronic depression (dysthymia) characterized by:
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> Severe Fatigue
> Apathy-Anhedonia
> Zero Motivation
> Memory /Concentration Problems
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> I have been taking Amphetamine in order to function with the fatigue, but it does nothing for the depression.
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> I have used Parnate for severe major depression in the past and have had a great response, but it hasn’t helped me with this current illness. I have tried augmentation with Lithium, Lamictal, Cytomel. Cytomel was the only thing that offered any additional benefit, but it was modest. I tried a few SSRI’s and TCA’s in the past without much success.
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> I just restarted Parnate 3-4 weeks ago after a 5-month break hoping it might work at a higher dose. My doc will go up to 100 mg or so; I just went from 80 to 90. If it does not work after a few weeks at 100mg, I am considering:
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> MIRAPEX or Other DA Agonist
> WELLBUTRIN
> SNRI (CYMBALTA)
> NARDIL(POSSIBLY)
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> My official diagnoses: Major Depression, Recurrent; Dysthymic Disorder.
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> After 2 non-stop years, I am really desperate and I don’t want to sink into MD Episode. I am trying (slowly) to come to terms with the fact that Parnate may not help anymore, and maintain hope that something else will.
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> I appreciate any similar experiences /ideas / etc…
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> Steve
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Hi Steve-My story sounds a lot like yours. I haven't been on Parnate - but I was on Nardil. It worked great for about 3 months then nothing. I had COMPLETE loss of sexual desire and function (I'm male) while on it - and I do mean COMPLETE. I gained weight too.
Now I am on Cymbalta, Klonopin, Concerta and Mirapex. I'm only on a small dose of the Mirapex .5mg so I don't think it's doing much - however I have no side effects from it. I think Cymblata really causes more anxiety. It's not any better than Effexor or an SSRI in my opnion.
Good luck
Jerry
poster:jerrympls
thread:426320
URL: http://www.dr-bob.org/babble/20041206/msgs/427404.html