Posted by Ritch on January 15, 2005, at 15:46:25
In reply to Re: Lamictal doesn't work anymore » Ritch, posted by catmint on January 15, 2005, at 14:55:02
> Hi Ritch,
>
> By the way, have you heard from Colin lately?Yes, last time I posted to him he was looking for advice on adding a psychostim for bipolar depression, I think that was just about a week or two ago. Haven't heard back on it yet. Oh, while the server was being switched I done some researching and there is derivative of Trileptal that is in clinical trials for bipolar.. it is licarbazapine. You may have read a few days ago about the approval of a unique extended-release form of carbamazepine for bipolar (can't remember the brand name now). Anyhow, here's some links related to licarbazapine.. I think they are still looking for volunteers for the trials..:
http://www.clinicaltrials.gov/ct/gui/show/NCT00099229
http://www.jclinpharm.org/cgi/content/abstract/44/8/906
http://www.ingentaconnect.com/content/sage/j377/2004/00000044/00000008/art00010Here's a text clip related to licarb. :
Novartis appear to have revived
licarbazepine, the monohydroxy
analog of oxcarbazepine, develop-
ment of which was suspended in
1999 as part of a pipeline reorgani-
zation process. Applications this year
have expanded the indications from
epilepsy to include tinnitus
(WO2004014391)
and
pain
(WO2004035041) and two applica-
tions this week claim anxiety, bipolar
disorder and neuropathic pain.Hmmm... it's interesting that they are pursuing an anxiety indication.... from what I read the side effect profile was supposed to be better than carbamazepine and oxcarbazepine. I'll be watching this one with interest for sure.
Oh yeah! Felbamate is also in clinical trials now for Bipolar. Hope you get to feeling better! Do you think that the Lamictal is *causing* your agitation and irritability?
poster:Ritch
thread:441138
URL: http://www.dr-bob.org/babble/20050113/msgs/442481.html