Posted by 3 Beer Effect on January 27, 2005, at 20:33:48
In reply to Thanks All, posted by verne on January 27, 2005, at 12:19:49
They have done trials for selegeline for depression & at 10 mg per day or less it is supposed to be ineffective for depression. I used to take oral selegeline that I ordered from Europe, & I didn't like it. I didn't find it to have much of an antidepressant effect, although it does seem to help with ADD symptoms. It also helps you do more work in the early morning hours & is somewhat activating.
However, I found the dry mouth & dry eyes to be absolutely intolerable so I had to go down to 5 mg (although I was taking it with Prozac 20 mg). It also caused a lot of social anxiety/shakiness & worst of all it makes you sweat excessively. 10 mg also made me somewhat irritable. It kind of felt like when you drink too much caffeine but without the great pleasure of the d-amphetamines. But I took the entire 10 mg dose in the morning while you are really supposed to split it into a breakfast & lunch dose (& always take it on a full stomach= much greater bioavailability). When the Prozac started working about 5 weeks later (my 2nd month on Selegeline) I actually felt good, but that could be just the Prozac working. You might have success by combining an SSRI with Selegeline since that is sort of like taking Parnate (although contrary to popular belief, Parnate is supposed to have little effects on dopamine receptors). If you have alcohol or drug problems the best thing about selegeline is that it reduces the pleasure of alcohol probably by inhibiting alcohol induced dopamine release & seems to reduce cravings.
My blood pressure seemed to go up on Selegeline, probably because it does metabolize to l-amphetamine & l-meth both of which release norepinephrine & raise your blood pressure.
Parnate & Nardil especially will actually lower your blood pressure over time as long as you don't eat anything with tyramine. (Sometimes the blood pressure drop is significant enough that you have to change positions or stand up slowly to avoid fainting.)
Cheers,
3 Beer Effect
poster:3 Beer Effect
thread:448571
URL: http://www.dr-bob.org/babble/20050124/msgs/448893.html