Posted by KaraS on June 18, 2005, at 16:06:45
In reply to Re: forget my last post! » KaraS, posted by ed_uk on June 18, 2005, at 9:33:11
> Hi K!
>
> >Would the sublingual selegiline also obviate the need for the MAOI diet?
>
> Well.....it's only been studied at low doses - where dietary restrictions are unnecessary anyway. I'd expect sublingual seleg to potentiate the hypertensive effect of tyramine to a lesser extent that oral seleg because most of the seleg will bypass the gut when absorbed via this route. I suppose you'd have to be careful not to swallow any though!
>
> I can't say the diet would be unnecessary with a high dose but I expect the chance of a hypertensive reaction would be somewhat reduced.
>
> The bioavailability of the sublingual tablets is not the same as the oral tablets. For Parkinson's disease, the recommended dose of Zelapar is 1.25mg/day, as opposed to 10mg for the oral tabs.
>
> RE the abstract from Prescrire Int. The journal is negative about EVERYTHING! I'm not kidding! I think they're just interested in health economics really.
>
> Ed xxx
Great answer! Thanks so much.K
poster:KaraS
thread:513663
URL: http://www.dr-bob.org/babble/20050617/msgs/515051.html