Posted by Ktemene on June 19, 2005, at 11:40:38
In reply to Re: Allergic to patch? » KaraS, posted by gromit on June 17, 2005, at 23:49:25
Even the sublingual selegiline is still ingested, and it is the ingesting part that causes the tyramine reaction. Of course, you could always try to spit out the sublingual selegiline, but it is unlikely that you would be able to get rid of all of it- some would still be going into your gut. The advantage of the patch is that the selegiline goes slowly and directly into the blood stream without going through the gut.
If you would like to try sublingual selegiline without paying for the liquid stuff, you could just get selegiline in capsule form. Open the capsule, and hold the powder in your mouth for a few moments. That is how I take my 5mg selegiline every day. The taste is not great, but the effect is the same as with Zydis selegiline.
On why the patch makes the diet restrictions unnecessary:
http://www.journals.elsevierhealth.com/periodicals/bps/article/PIIS0006322302018929/abstractAndrewB says that 2.5mg per day Selegiline will result in close to complete MAO-B inhibition.
http://www.dr-bob.org/babble/20010417/msgs/60824.htmlAdam says that 5mg per day will give near complete MAO-B inhibition.
http://www.dr-bob.org/babble/20010310/msgs/56813.html> > Would the sublingual selegiline also obviate the need for the MAOI diet? If so, then why do we need to wait for the patch at all? Maybe it's a lot harder to get doctors to prescribe the sublingual selegiline where as if the patch were released and promoted here, then mainstream doctors would be willing to prescribe it.
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> I've wondered the same thing about sublingual selegiline, I know I've read that SHOULD be the case. I don't think there is a sublingual form available in the US. I imported some liquid, can't remember the measurement they use but I think it amounted to 300 mg, for about $90. Depending on your dose that could be pretty reasonable. At 10 mg a day it isn't, at least for me.
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> I've searched for, but never found again a post where someone claimed a really low dose, like 1-2 mg a day, would eventually give almost complete inhibition.
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> Rick
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poster:Ktemene
thread:513663
URL: http://www.dr-bob.org/babble/20050617/msgs/515482.html