Posted by CamW on September 16, 2005, at 3:41:03
In reply to Re: Low dose dexedrine contra. with nardil? » jonh kimble, posted by Chairman_MAO on September 13, 2005, at 8:42:29
Chairman - After doing an extensive literature search I have to agree with you that combining MAOIs with stimulants is a viable alternative in certain instances. Individual genetic variations in monoamine oxidase activity must be taken into account, and may account for many instances of reported hypertensive crisis with this combination.
Most amphetamine/MAOI deaths reported were from the 1960s, with very few being reported in the recent literature. More recent deaths seem to be reported when MAOIs have been mixed with MDMA (eg. moclobemide/MDMA (2003); phenelzine/MDMA (1987). Deaths from MAOI/MDMA seem to result from hypertensive crisis and/or serotonin syndrome. I would not recommend using MDMA (aka Ecstasy) while taking an MAOI; I doubt that the benefits outweigh the risks.
While the dangers of MAOI/stimulant may be overstated, I would not say that the risk is "markedly exaggerated". Appropriate caution does need to be taken, and if anyone would decide to try this combination, I would strongly recommend not undertaking a trial without close monitoring by a physician.
Also, I think that you'd agree that the use of Dexedrine Spansules would be contraindicated in favor of the shorter acting version of the drug. And you are very correct that "low and slow" is the way to go.
- Cam
poster:CamW
thread:554271
URL: http://www.dr-bob.org/babble/20050914/msgs/555542.html