Posted by CamW on September 16, 2005, at 4:20:15
In reply to Re: Low dose dexedrine contra. with nardil? » CamW, posted by SLS on September 12, 2005, at 23:48:40
Hey Scott - I'm not doing too bad. I've been med-free and in remission (more or less) for better than a year and a half. Cool, huh? Who'd a thunk it, eh?
So, how are you doing, buddy? I've been thinking of you off and on (still at the same email?; mine's change, but I can still be reached through the old one). As I've told you last time we exchanged short notes; I no longer specialize in strictly in psychiatry. I have been following the advances in consciousness research, as a hobby. In a way, psychopharmacology and consciousness are related.
Anyway, I posted a reply to Chairman MAO (I think that I forgot to direct the post to him), showing the results of a literature search. I haven't done that in a long time. It was sorta fun.
Parnate™ (tranylcypromine) and Dexedrine™ (dextroamphetamine) is not as contraindicated as I had thought, but there is a real danger of hypertensive crisis, especially within the first couple weeks of therapy. It seems that genetics plays a roll in the vulnerability to this side effect, as well as some cases of pronounced and persistent hypotension (beyond the ordinary and transient ataxia and dizziness that is common with MAOI therapy). You do need someone to follow your progress until stabilized, but that should only be needed for a month or so. Perhaps starting at 2.5mg once daily and slowly increase.
Really, I'd like to see a few more controlled studies done before I am comfortable recommending this combination for anyone with less of an understanding of psychopharmacology than you. If you do decide to try this combination, be careful.
When I look back at my own therapy, I do realize that the addition of 10 mg of Dexedrine Spansules (am & noon) really did augment the 300mg of Wellbutrin™ (bupropion) and 450 mg of Effexor XR™ (venlafaxine). It was not until after the addition of the Dexedrine that I acheived full remission. I don't think that I really appreciated the skill of my psychiatrist at the time; the Dexedrine was his idea. At the time I just thought that the stimulant was just off-setting the "sludge-brained" hangover effect of the high dose Effexor, so that I was able to go to work before 2:00 pm. Perhaps there was more to the mechanism of action than I realized.
Take care &, if you like, email me and I'll send you a couple of the interesting papers that I found. - Cam
poster:CamW
thread:554271
URL: http://www.dr-bob.org/babble/20050914/msgs/555545.html