Posted by tecknohed on October 23, 2005, at 22:06:23
In reply to Re: Does Nardil alias Phenelezine interact badly w » tecknohed, posted by Phillipa on October 21, 2005, at 18:27:14
> When the patch comes out will it avoid food restrictions? Fondly, Phillipa
Hi Phillipa
I'm afraid I haven't really looked into the patch much. However, I think that the Tyramine food reaction caused by 'ingested' MAOIs has something to do with Tyramine in the stomache and its effect on noradrenaline & adrenaline (norepinephrine & epinephrine). A patch is absorbed through the skin into the bloodstream completely bypassing the gut where the tyramine reaction normally originates. (?)
"R. Tyramine, is an amino acid which is found in various foods, and is an indirect sympathomimetic that can cause a hypertensive reaction in patients receiving MAOI therapy. Monoamine oxidase is found in the gastrointestinal tract and inactivates tyramine; when drugs prevent the catabolism of exogenous tyramine, this amino acid is absorbed and displaces norepinephrine from sympathetic nerve ending and epinephrine from the adrenal glands. If a sufficient amount of pressor amines are released, a patient may experience a severe occipital or temporal headache, diaphoresis, mydriasis, nuchal rigidity, palpitations, and the elevation of both diastolic and systolic blood pressure may ensue (Anon, 1989; Da Prada et al, 1988; Brown & Bryant, 1988)."
http://deoxy.org/maoidiet.htmRegards
teck
poster:tecknohed
thread:569485
URL: http://www.dr-bob.org/babble/20051017/msgs/571190.html